Read our Director George Papadopoulos’s recently published joint manuscript, in the Journal of Medical Economics; Cost-effectiveness analysis of arthroscopic injection of a bioadhesive hydrogel implant in conjunction with microfracture for the treatment of focal chondral defects of the knee – an Australian perspective, Journal of Medical Economics, 25:1, 712-721, DOI: 10.1080/13696998.2022.2078574
Our manuscript shows that JointRep, a bioadhesive hydrogel, arthroscopically injected together with microfracture surgery to facilitate cartilage regeneration is a cost-effective treatment option compared to microfracture alone from the Australian health care system perspective.
We developed an economic model to research the cost-effectiveness of using JointRep together with microfracture surgery compared to microfracture surgery alone to facilitate cartilage regeneration.
- Clinical outcomes were assessed using the Western Ontario and McMaster Universities Osteoarthritis index scores (WOMAC), which is a validated patient-reported tool measuring pain, stiffness, and physical function.
- Utility scores were derived by mapping the WOMAC scores to EQ-5D scores using a published algorithm.
- Australian cost inputs were from AR-DRGs, Medicare Benefits Schedule, and Prostheses List.
Over a 3-year time horizon,
- the mean total discounted cost per patient for JointRep with microfracture surgery was estimated to be $12,996 compared to $6,974 for microfracture surgery alone, a small incremental cost of $6,022
- the model estimated total quality adjusted life years (QALYs) were higher for JointRep with microfracture surgery (2.61) compared to microfracture surgery alone (1.66), an incremental gain of 0.95 QALY.
- Sensitivity analyses conducted showed the results were substantially robust to varying parameters and assumptions.
The incremental cost effectiveness ration (ICER) was $6,328 which indicates that JointRep plus microfracture is value for money compared to microfracture surgery alone within the Australian healthcare system.
The full manuscript is free to download here: Full article: Cost-effectiveness analysis of arthroscopic injection of a bioadhesive hydrogel implant in conjunction with microfracture for the treatment of focal chondral defects of the knee – an Australian perspective (tandfonline.com)